Course Materials

Advanced Problems in Pharmacology (4 credit hours)

3 hours/week / 1 hour reading period/week

Meets: Lecture: Thursday 1:00 pm - 4:00 pm, Pharmacology Conference Room
Tuesday 9/16 1:00- 4:00 pm, Pharmacology Conference Room
Laboratory: Thursday 2:00 p.m. - 5:00 p.m., TBA
Grading Midterm 40% (written)
Final 40% (written)
Class participation 20%

Course Coordinator: Dr. Yousef Tizabi

Objectives: This course is designed to present state-of-the-art and advanced pharmacological concepts in areas critical to the functioning of a modern research pharmacologist. The laboratory components will illustrate concepts introduced during the seminar/discussions.

Format: Interactive graduate seminar. Students will be provided with a select bibliography at least 7 days prior to each session. Each student is expected to throughly read each citation and be prepared for interactive classroom participation.

9/11 Introduction to Course - Taylor
General Principles
Absorption - Bowen
9/16 General Principles (TUESDAY)
Metabolism- Cohen
Protein Binding I -John Holladay ( 3PM)
9/18 General Principles
Drug Elimination- Ferguson
Protein Binding II- John Holladay (3PM)
9/25 Dose Response in Pharmacology
Graphics Methods in Pharmacology Research
10/2 Physical Chemistry of Pharmacology

Computational Biology Laboratory- Southerland

10/9 Quantitative Structure-Activity-Relationships (SAR)- Hanig
Drug Receptor Interactions- Akinshola
10/16 Molecular Pharmacology - Vocabulary and Basic Principles- Wang
10/23 MidTerm Exam (Written)
10/30 Signal Transduction Mechanisms (G protein, IP3, etc.)- Copeland
Pharmacology of Drug receptors
1. G Protein Linked Receptors- Copeland
2. Ion Channel Receptors- Tizabi
11/6 Pharmacology of Drug receptors
3. Voltage Activated Channel Receptors including Ca Channel Receptors- Gatti
4. Ligand Gated Ion Channel Receptors- Classical and others-Akinshola
11/13 Pharmacology of Drug receptors
5. Excitatory and Inhibitory Channel Receptors- Wang
6. Neuropeptides- Massari
11/20 Quantitative methods in drug research- Laboratory-Massari
12/4 Apotosis and Cell Death - Copeland
Nitric Oxide - Gatti
Pharmacogenetics - Tizabi/Taylor
12/11 Final Exam (Written)

Suggested General Reading Resources ( available from departmental library):

  1. Alexander, S.P.H. & Peters, J.A. 1997 Receptor & Ion Channel Nomenclature Supplement: Trends in Pharmacological Sciences, Eighth Edition,1997.
  2. Foreman, John C. & Johansen, Torben. Textbook of Receptor Pharmacology, CRC Press, 1996.
  3. Kenakin, Terry. Molecular Pharmacology, Blackwell Science, Inc., 1997.
  4. Lauffenburger, Douglas A. & Linderman, Jennifer, J. Receptors: Models for Binding, Trafficking, and Signaling, Oxford University Press, 1993.
  5. Limbird, Lee E. Cell Surface Receptors: A Short Course on Theory and Methods, Second Edition, Kluwer Academic Publishers, 1996.
  6. Pratt, William B., Taylor, Palmer. Principles of Drug Action: The Basis of Pharmacology, Third Edition, Churchill Livingstone, 1990.
  7. Shargel, Leon & Yu, Andrew B.C. Applied Biopharmaceutics and Pharmacokinetics, Third Edition, Appleton & Lange, 1993.
  8. Tallarida, R.J., Raffa, R.B., McGonigle, P. Principles in General Pharmacology, Springer-Verlag, 1988.